Effect of a Xenogeneic Urinary Bladder Injectable Bioscaffold on Lameness in Dogs with Osteoarthritis of the Coxofemoral Joint (Hip): A randomized, Double Blinded Controlled Trial

More than 20% of all dogs in the United States suffer from lameness and pain associated with chronic osteoarthritis (OA). Many times the current therapeutic modalities are not well tolerated by the pet leaving, few choices for alleviating suffering. Regenerative medicine brings new modalities that may aid dogs that either do not respond to or cannot tolerate traditional therapy. The present study evaluated the efficacy of porcine urinary bladder extracellular matrix (UBMECM), an acellular bio-inductive scaffold, to treat dogs with osteoarthritis of the hip joint. This study demonstrates that a single intra-articular injection of UBM-ECM significantly improved activity, lameness, and range of motion scores compared to control dogs. This is the first randomized controlled clinical trial reporting the effectiveness of a bioinductive scaffold in dogs with OA.